Ultrasound imaging of hepatocellular adenoma using the new. The diagnosis of hepatocellular adenomas hca may occasionally be. The tumor cells often have an increased cell size due to increased intracellular glycogen or fat accumulation but show regular nuclei without atypia. A new histologybased classification has been proposed but to date, the corre.
The typical histopathological features of classical fnh include a firm, welldelimited but not encapsulated lesion composed of hepatocellular. Hepatocellular carcinoma hepatocellular carcinoma hcc, a malignant tumor of hepatocytes, may exhibit any or all of the cytologic andor architectural characteristics of hepatocellular differentiation, along with features of malignancy. Thirty hepatocellular adenomas were classified in subtypes. Inflammatory hepatocellular adenomas developed in the. Treatment options have focused on conservative management for the straightforward. Histopathologic evidence of hccs occurring within regions of otherwise. Pathological diagnosis of liver cell adenoma and focal nodular. Update on the new classification of hepatic adenomas. In conventional histology hepatocellular adenoma resembles normal liver tissue but may show pseudoglandular architecture, especially when arising in a patient with anabolic use. Histopathology images of hepatocellular carcinoma by. Histopathology liverhepatocellular carcinoma in cirrhosis.
Discovery of this tumor is usually as an incidental finding, correlated with the use of oral contraceptives, or pregnancy. Most of the time, there is a clear difference on gross pathology or. Histological and immunohistochemical revision of hepatocellular adenomas. Hepatic adenoma is an uncommon, benign, hepatic neoplasm that typically occurs in women of childbearing age, often with a history of longterm use of oral contraceptive drugs. Hepatocellular adenoma in glycogen storage disorder type i. A hepatocellular adenoma is a benign tumor composed of hepatocytes that resemble normal cells, although some tinctorial variation and nuclear atypia can be encountered craig et al. Pathological diagnosis of hepatocellular cellular adenoma.
Hca usually manifests as a single lesion, but can be multiple the term adenomatosis is appropriate when there are more than 10. Hepatocellular adenoma hca is a rare, benign liver tumor. Histopathology of hepatocellular carcinoma springerlink. Hepatocellular adenomas hca are rare benign liver tumors. Molecular classification of hepatocellular adenomas. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Clinical, molecular, and pathologic characteristics. Hepatocellular adenoma an overview sciencedirect topics. Glycogen storage disease type i is a metabolic disorder resulting from deficiency of the glucose. Histopathology liver hepatocellular carcinoma in cirrhosis of the liver. Adenoma is a non cancerous tumor that begins in the epithelium of mucosa or in the glands and ducts of the endocrine hormone producing glands or.
Hepatocellular carcinoma hcc is the most frequent primary liver malignancy, mostly occurring in the context of chronic liver diseases leading to. Hepatocellular adenoma hca is a rare, benign, liver neoplasm. Hepatocellular adenomas hca are rare benign liver tumors with the capacity to undergo malignant transformation. Hepatocellular adenomas are rare benign liver tumors usually developing in young women using oral contraception. Welldifferentiated hcc, however, may be difficult to distinguish from normal hepatic parenchyma or hepatocellular adenomas. The two main complications are hemorrhage 1020% and malignant transformation into hepatocellular carcinoma hepatocellular adenomas have a small risk of malignant transformation with estimated rates of less than 5 % 3, 2527. Review article update on the new classification of hepatic adenomas clinical, molecular, and pathologic characteristics sadhna dhingra, md. Histopathologic features of hepatocellular carcinoma.
Abstracthepatocellular adenoma is a rare benign liver tumor. Recent advances in the morphologic and molecular classification of hca identified bhca as the subtype most commonly associated to malignant transformation. Pdf histological and immunohistochemical revision of. Relevance of morphological features for hepatocellular adenoma. It is a heterogeneous entity and a molecular classification is now widely accepted. Hepatic adenoma ha is an uncommon, benign neoplasm of the liver, with hemangioma and focal nodular hyperplasia fnh being more frequent lesions.
733 1487 205 508 424 732 752 642 810 256 1176 1001 978 1196 692 1045 771 163 385 1201 630 1049 1353 817 325 909 1268 1041 554